🎓 🎉 Congratulations, Martin Grashei to an excellent PhD defense!

Martin took us away in his presentation on “Novel hyperpolarized 13C MRI techniques for quantification of pH and metabolism in vivo”

His work improves various facets of hyperpolarized 13C-MRI, particularly for imaging metabolism and pH. In vitro pH dependencies of relaxation time constants of hyperpolarized probes were exploited to reveal new ways for probe preparation and acquisition strategies for imaging pH. In addition, a deeper insight into the metabolic plasticity of tumor cells and its effects on hyperpolarized 13C was gained. In vivo, a new pH probe and uptake strategy for multiparametric hyperpolarized 13C in tumors and kidneys was presented. New analytical approaches for pH mapping using deep learning were developed, and the feasibility of hyperpolarized imaging of metabolism and pH within a multimodal clinical PET/MRI protocol in feline tumor patients was demonstrated.