A new paper from our group in collaboration with NVision Imaging Technologies on hyperpolarized 13C-pyruvate metabolic MRI using both PHIP-SAH and dDNP online in Advanced Science.

In this study, we present the culmination of several recent advances in the polarization of [1-13C]pyruvate via PHIP-SAH (Parahydrogen Induced Polarization via Side-Arm Hydrogenation).

In a fully automated process, we obtained purified solutions of pyruvate at physiological pH and preclinically relevant volumes (up to 2 ml), concentrations (70-160 mM), and polarization levels (PHIP: 17.8 ± 1.2 %; d-DNP: 22.8 ± 5.4 %) at the time of injection.

Big thanks to everybody involved in this team effort (Luca Nagel, Martin Gierse, Wolfgang Gottwald, Zumrud Ahmadova, Martin Grashei, Dr. Christoph Alexander Müller, Jonas Handwerker, Michael Keim, Ilai Schwartz, Sella Brosh and many more) and thanks to our supporters and funders:

Bundesministerium für Bildung und Forschung
Technische Universität München
Munich Institute of Biomedical Engineering
Bayerische Akademie der Wissenschaften
DKFZ German Cancer Research Center