3D multi-voxel PRESS and semi-LASER MRS of hyperpolarized 13C nuclei

In our new paper we demonstrate a novel technique using 3D multi-voxel PRESS and semi-LASER MRS of hyperpolarized 13C nuclei. This enables “virtual biopsies” of pH, metabolic activity and other MR biomarkers read-out via spectroscopic measurements.

👏 Great team effort led by Wolfgang Gottwald and supported by Luca Nagel, Martin Grashei, Sebastian Bauer, Nadine Setzer, Florian Gaksch, Sandra Sühnel, Jason Skinner, Rickmer Braren, Irina Heid and Geoffrey Topping.

We are grateful for funding support by Deutsche Forschungsgemeinschaft (DFG) – German Research Foundation through the Emmy Noether Program and the Bundesministerium für Forschung, Technologie und Raumfahrt.

Research was conducted at TUM Klinikum Rechts der Isar, Munich Institute of Biomedical Engineering, Technische Universität München

https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.30544