Temperature dependent chemical shifts of pyruvate and lactate

Did you ever wonder why 13C pyruvate and lactate resonances shift in your NMR spectrum?

💡 In our new paper we demonstrate temperature dependent chemical shifts of pyruvate and lactate that enable in vivo hyperpolarized 13C MRSI thermometry.

👏 Great team effort led by Wolfgang Gottwald and supported by Luca Nagel, Jason Skinner, Martin Grashei, Sandra Sühnel, Nadine Setzer, Wolfgang Eisenreich, Mary McLean, Ferdia Gallagher, Jae Mo Park, Zumrud Ahmadova, Martin Gierse, Senay Karaali, Stephan Knecht, Ilai Schwartz, Irina Heid, Geoffrey Topping and Frits van Heijster.

We are grateful for funding support by Deutsche Forschungsgemeinschaft (DFG) – German Research Foundation through the Emmy Noether Program, from the European Union’s Horizon 2020 program and the Bundesministerium für Forschung, Technologie und Raumfahrt (QuE-MRT project).

Research was conducted at TUM Klinikum Rechts der Isar, Munich Institute of Biomedical Engineering, Technische Universität München together with our collaborators from University of Cambridge, NVision Imaging Technologies and UT Southwestern Medical Center.

https://www.nature.com/articles/s44303-025-00081-3